Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T73712
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| Former ID |
TTDR00634
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| Target Name |
Fatty acid-binding protein, liver
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| Gene Name |
FABP1
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| Synonyms |
14 kDa selenium-binding protein; 14-kDa fatty-acid binding protein; L-FABP; FABP1
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| Target Type |
Discontinued
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| Disease | Gout [ICD9: 274.00274.1274.8274.9; ICD10: M10] | ||||
| Function |
Binds free fatty acids andtheir coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
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| BioChemical Class |
Calycin family
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| Target Validation |
T73712
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| UniProt ID | |||||
| Sequence |
MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQ
NEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVF KRISKRI |
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| Drugs and Mode of Action | |||||
| Pathways | |||||
| KEGG Pathway | PPAR signaling pathway | ||||
| Fat digestion and absorption | |||||
| Reactome | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | ||||
| PPARA activates gene expression | |||||
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| WikiPathways | Nuclear Receptors Meta-Pathway | ||||
| PPAR Alpha Pathway | |||||
| Selenium Metabolism and Selenoproteins | |||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| References | |||||