Target Information

Target General Infomation
Target ID
T62912
Former ID
TTDR00261
Target Name
Corticotropin-lipotropin
Gene Name
POMC
Synonyms
Pro-opiomelanocortin; POMC
Target Type
Research
Function
Beta-endorphin and Met-enkephalin are endogenous opiates.
UniProt ID
P01189
Sequence
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE
Agonist Dihydromorphine Drug Info [551379]
Pathways
KEGG Pathway Melanogenesis
Adipocytokine signaling pathway
NetPath Pathway AndrogenReceptor Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Opioid proopiomelanocortin pathway
Pathway Interaction Database Glucocorticoid receptor regulatory network
Syndecan-3-mediated signaling events
PathWhiz Pathway Corticotropin Activation of Cortisol Production
Reactome Androgen biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols
Peptide ligand-binding receptors
G alpha (s) signalling events
G alpha (i) signalling events
WikiPathways Metabolism of steroid hormones and vitamin D
Metabolism of amino acids and derivatives
Peptide hormone biosynthesis
Corticotropin-releasing hormone
Opioid Signalling
Phase 1 - Functionalization of compounds
GPCR ligand binding
GPCR downstream signaling
References
Ref 551379Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. Epub 2006 Jun 13.