Target Information

Target General Infomation
Target ID
T04741
Former ID
TTDR00945
Target Name
Phosphoribosylaminoimidazolecarboxamide formyltransferase
Gene Name
ATIC
Synonyms
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; AICARFT; ATIC
Target Type
Research
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
BioChemical Class
Methyltransferase superfamily
Target Validation
T04741
UniProt ID
P31939
EC Number
EC 2.1.2.3
Sequence
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT
HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL
CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS
AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV
ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT
GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA
FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
Inhibitor FAICAR Drug Info [528699]
NSC-126445 Drug Info [527350]
NSC-26699 Drug Info [527350]
NSC-292213 Drug Info [527350]
NSC-30171 Drug Info [527350]
NSC-324572 Drug Info [527350]
NSC-37031 Drug Info [527350]
NSC-37173 Drug Info [527350]
NSC-45592 Drug Info [527350]
NSC-47729 Drug Info [527350]
NSC-58046 Drug Info [527350]
NSC-88915 Drug Info [527350]
References
Ref 527350J Med Chem. 2004 Dec 30;47(27):6681-90.Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
Ref 528699J Biol Chem. 2007 Apr 27;282(17):13033-46. Epub 2007 Feb 26.Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.