Drug Information

Drug General Information
Drug ID
D0T6JO
Former ID
DNC012054
Drug Name
Indol-1-yl-propyl-pyridin-4-yl-amine
Synonyms
Indol-1-yl-propyl-pyridin-4-yl-amine (Besipirdine)
Indication Discovery agent Investigative [534087]
Structure
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3D MOL
Canonical SMILES
CCCN(C1=CC=NC=C1)N2C=CC3=CC=CC=C32
InChI
1S/C16H17N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h3-11,13H,2,12H2,1H3
InChIKey
OTPPJICEBWOCKD-UHFFFAOYSA-N
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Inhibitor [534087]
Sodium channel protein type 5 subunit alpha Target Info Inhibitor [525961]
Alpha-2B adrenergic receptor Target Info Inhibitor [534087]
Sodium channel Target Info Inhibitor [525961]
Alpha-2C adrenergic receptor Target Info Inhibitor [534087]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04261:Adrenergic signaling in cardiomyocyteshsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04728:Dopaminergic synapsehsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Cardiac Progenitor DifferentiationWP58:Monoamine GPCRs
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 534087J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Ref 525961J Med Chem. 2001 Jan 18;44(2):115-37.Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Ref 534087J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.