TTD | Drug: D02ZQS

Drug General Information
Drug ID	D02ZQS
Former ID	DIB018022
Drug Name	GSK269962A
Synonyms	GSK-269962A; GSK269962; GSK 269962; GSK-269962; aminofurazanyl-azabenzimidazole 6n
Drug Type	Small molecular drug
Indication	Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25]		Clinical trial	[528461]
Formula	C29H30N8O5
InChI	InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38)
InChIKey	YOVNFNXUCOWYSG-UHFFFAOYSA-N
PubChem Compound ID	16095342
PubChem Substance ID	24741762, 28702919, 40064106, 46514412, 50076551, 103504608, 103905674, 124349886, 135692870, 135697663, 137275847, 137618273, 141786191, 144116032, 152344382, 176485182, 180371700, 210275244, 210280884, 223704822, 224207972, 228010724, 241376758, 243106439, 249565717, 249618050, 252157709, 252159921, 252479007
Target and Pathway
Target(s)	Rho associated protein kinase 2	Target Info	Inhibitor	[528461]
Target(s)	Rho-associated protein kinase 1	Target Info	Inhibitor	[528461]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	Sphingolipid signaling pathway
	Vascular smooth muscle contraction
	Wnt signaling pathway
	Axon guidance
	Focal adhesion
	Platelet activation
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton
	Oxytocin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Salmonella infection
	Pathways in cancer
	Proteoglycans in cancerhsa04022:cGMP-PKG signaling pathway
	TGF-beta signaling pathway
	Proteoglycans in cancer
	MicroRNAs in cancer
PANTHER Pathway	Cytoskeletal regulation by Rho GTPaseP00016:Cytoskeletal regulation by Rho GTPase
	Inflammation mediated by chemokine and cytokine signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	RhoA signaling pathway
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	PLK1 signaling events
	PAR4-mediated thrombin signaling events
	PAR1-mediated thrombin signaling events
	Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
	Noncanonical Wnt signaling pathway
	EPHB forward signaling
	Thromboxane A2 receptor signaling
	amb2 Integrin signaling
	Integrins in angiogenesis
	EPHA forward signaling
	Stabilization and expansion of the E-cadherin adherens junction
	Signaling events mediated by VEGFR1 and VEGFR2
	N-cadherin signaling events
Reactome	EPHB-mediated forward signaling
	EPHA-mediated growth cone collapse
	G alpha (12/13) signalling events
	Sema4D induced cell migration and growth-cone collapse
	VEGFA-VEGFR2 Pathway
	RHO GTPases Activate ROCKsR-HSA-111465:Apoptotic cleavage of cellular proteins
	RHO GTPases Activate ROCKs
WikiPathways	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	Focal Adhesion
	JAK/STAT
	Spinal Cord Injury
	Pathogenic Escherichia coli infection
	Leptin signaling pathway
	Semaphorin interactions
	Integrin-mediated Cell Adhesion
	GPCR downstream signaling
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathwayWP524:G13 Signaling Pathway
	EGF/EGFR Signaling Pathway
	TGF beta Signaling Pathway
	AGE/RAGE pathway
	Regulation of Microtubule Cytoskeleton
	Apoptotic execution phase
	Androgen receptor signaling pathway
References
Ref 528461	Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. Epub 2006 Oct 3.
Ref 528461	Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. Epub 2006 Oct 3.

Drug Information