Drug Information

Drug General Information
Drug ID
D0L7OM
Former ID
DNC010200
Drug Name
STEPHOLIDINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543094]
Formula
C19H21NO4
InChI
InChI=1S/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
InChIKey
JKPISQIIWUONPB-HNNXBMFYSA-N
PubChem Compound ID
6917970
PubChem Substance ID
12013869, 14801735, 17194632, 43529372, 51052690, 62689478, 99381449, 103579226, 114787232, 128288631, 134347405, 134358422, 137643394, 160828628, 160857667, 162198614, 163093641, 163390371, 163621091, 163686414, 163913792, 164233787, 172860722, 184812103, 204429898, 223590116, 235345997, 249855637, 250201823, 251912205, 251915273, 252067651, 252166582, 252416263
Target and Pathway
Target(s) D(1B) dopamine receptor Target Info Inhibitor [530374]
D(3) dopamine receptor Target Info Inhibitor [530374]
D(2) dopamine receptor Target Info Inhibitor [530374]
D(4) dopamine receptor Target Info Inhibitor [530374]
Dopamine D1 receptor Target Info Inhibitor [530374]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
References
Ref 543094(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8370).
Ref 530374Bioorg Med Chem. 2009 Oct 1;17(19):6898-907. Epub 2009 Aug 20.Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?.