Drug Information

Drug General Information
Drug ID
D0O3NY
Former ID
DNC008330
Drug Name
AM-1241
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540276]
Formula
C22H22IN3O3
InChI
InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
InChIKey
ZUHIXXCLLBMBDW-UHFFFAOYSA-N
PubChem Compound ID
10141893
PubChem Substance ID
15133103, 22543339, 24891092, 29217481, 39980315, 49689355, 50075253, 57374267, 76284474, 103570243, 104253201, 123220371, 125333900, 125333901, 134223221, 134345535, 135727823, 136367459, 139525211, 140908975, 160829666, 162038067, 162108993, 163094098, 163394831, 163843884, 172855452, 175608141, 178100350, 185992953, 204434093, 228185242, 242810617, 245207288, 249853586, 249964872, 250212640, 252074940, 252437430, 252457872
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [530525]
Cannabinoid receptor 1 Target Info Inhibitor [530525]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 540276(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3316).
Ref 530525J Med Chem. 2010 Jan 14;53(1):295-315.Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.