Drug Information

Drug General Information
Drug ID
D03CPB
Former ID
DIB020811
Drug Name
RKI-1447
Synonyms
RKI1447; compound 5g [PMID 23275831]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532172]
Formula
C16H14N4O2S
InChI
InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey
GDVRVPIXWXOKQO-UHFFFAOYSA-N
PubChem Compound ID
60138149
PubChem Substance ID
143472448, 162112107, 172660019, 175426346, 208012521, 210275324, 210280973, 223378476, 226088031, 228660263, 242059974, 242612641, 249565832, 252160841, 252216210, 252451358, 252554234
Target and Pathway
Target(s) Myosin light chain kinase, smooth muscle and non-muscle isozymes Target Info Inhibitor [532172]
mRNA of DMPK Target Info Inhibitor [532172]
p21 protein (Cdc42/Rac)-activated kinase 1 Target Info Inhibitor [532172]
CDC42 binding protein kinase alpha (DMPK-like) Target Info Inhibitor [532172]
LIM domain kinase 1 Target Info Inhibitor [532172]
protein kinase N1 Target Info Inhibitor [532172]
Rho associated protein kinase 2 Target Info Inhibitor [532172]
Rho-associated protein kinase 1 Target Info Inhibitor [532172]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Platelet activation
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Gastric acid secretionhsa04022:cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Wnt signaling pathway
Axon guidance
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pathways in cancer
Proteoglycans in cancerhsa04022:cGMP-PKG signaling pathway
TGF-beta signaling pathway
Proteoglycans in cancer
MicroRNAs in cancer
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathwayP00016:Cytoskeletal regulation by Rho GTPaseP00016:Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathway
CCKR signaling map ST
Pathway Interaction Database Aurora B signalingrhoa_pathway:RhoA signaling pathway
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
PLK1 signaling events
PAR4-mediated thrombin signaling events
PAR1-mediated thrombin signaling events
Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
RhoA signaling pathway
Noncanonical Wnt signaling pathway
EPHB forward signaling
Thromboxane A2 receptor signaling
amb2 Integrin signaling
Integrins in angiogenesis
EPHA forward signaling
Stabilization and expansion of the E-cadherin adherens junction
Signaling events mediated by VEGFR1 and VEGFR2
N-cadherin signaling events
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Muscle/Heart Contraction
Reactome Smooth Muscle ContractionR-HSA-3928662:EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKsR-HSA-111465:Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
RHO GTPases Activate ROCKs
WikiPathways Regulation of Actin Cytoskeleton
Focal Adhesion
Endothelin Pathways
Muscle contraction
MicroRNAs in cardiomyocyte hypertrophyWP524:G13 Signaling Pathway
JAK/STAT
Spinal Cord Injury
Pathogenic Escherichia coli infection
Leptin signaling pathway
Semaphorin interactions
Integrin-mediated Cell Adhesion
GPCR downstream signaling
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathwayWP524:G13 Signaling Pathway
EGF/EGFR Signaling Pathway
TGF beta Signaling Pathway
AGE/RAGE pathway
Regulation of Microtubule Cytoskeleton
Apoptotic execution phase
Androgen receptor signaling pathway
References
Ref 532172Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. Epub 2012 Jan 27.
Ref 532172Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. Epub 2012 Jan 27.