TTD | Drug: D06LJL

Drug General Information
Drug ID	D06LJL
Former ID	DIB019503
Drug Name	compound 46
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528000]
Formula	C29H33FN6O4S
InChI	InChI=1S/C29H33FN6O4S/c1-39-25-14-23-24(15-26(25)40-11-3-8-36-9-6-19(17-37)7-10-36)32-18-33-28(23)35-29-31-16-22(41-29)13-27(38)34-21-5-2-4-20(30)12-21/h2,4-5,12,14-16,18-19,37H,3,6-11,13,17H2,1H3,(H,34,38)(H,31,32,33,35)
InChIKey	QNJAKUMXJFWQOG-UHFFFAOYSA-N
PubChem Compound ID	9916282
PubChem Substance ID	14886767, 24195338, 45987932, 78929350, 103478921, 104066370, 141775357, 180189213, 230915134, 244942080, 252166567
Target and Pathway
Target(s)	mRNA of Aurora B	Target Info	Inhibitor	[528000]
Target(s)	Aurora protein kinase	Target Info	Inhibitor	[528000]
KEGG Pathway	Oocyte meiosis
Pathway Interaction Database	Aurora B signaling
	Signaling by Aurora kinases
	Aurora C signaling
	FOXM1 transcription factor network
	Aurora A signaling
Reactome	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate Formins
	Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
WikiPathways	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Regulation of Microtubule Cytoskeleton
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
	JAK/STAT
	Gastric Cancer Network 1
	Integrated Breast Cancer Pathway
	APC/C-mediated degradation of cell cycle proteins
References
Ref 528000	J Med Chem. 2006 Feb 9;49(3):955-70.Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
Ref 528000	J Med Chem. 2006 Feb 9;49(3):955-70.Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.

Drug Information