TTD | Drug: D0W0BL

Drug General Information
Drug ID	D0W0BL
Former ID	DNC006930
Drug Name	3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528490]
Formula	C9H10N6O
Canonical SMILES	C1=CC(=CC(=C1)O)NN=C2C(=NN=C2N)N
InChI	1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,12,16H,(H4,10,11,13,14,15)
InChIKey	LCQNXRGFMXJDJJ-UHFFFAOYSA-N
PubChem Compound ID	9964499
Target and Pathway
Target(s)	Cell division protein kinase 9	Target Info	Inhibitor	[528490]
	Cell division protein kinase 2	Target Info	Inhibitor	[528490]
	Cyclin-A2	Target Info	Inhibitor	[528490]
	G1/S-specific cyclin E1	Target Info	Inhibitor	[528490]
KEGG Pathway	Transcriptional misregulation in cancerhsa04068:FoxO signaling pathway
	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	PI3K-Akt signaling pathway
	Progesterone-mediated oocyte maturation
	Hepatitis B
	Measles
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Prostate cancer
	Small cell lung cancerhsa03030:DNA replication
	Base excision repair
	Nucleotide excision repair
	Mismatch repair
	HTLV-I infectionhsa04110:Cell cycle
	MicroRNAs in cancer
	Small cell lung cancer
NetPath Pathway	EGFR1 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	p53 pathway
	p53 pathway feedback loops 2P00013:Cell cycle
	Parkinson disease
	p53 pathway feedback loops 2
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by PRL
	p73 transcription factor network
	E2F transcription factor network
	ATR signaling pathway
	mTOR signaling pathway
	IL2-mediated signaling events
	FoxO family signaling
	FOXM1 transcription factor network
	BARD1 signaling events
	p53 pathway
	Regulation of retinoblastoma proteinprlsignalingeventspathway:Signaling events mediated by PRL
	PLK3 signaling events
	Regulation of retinoblastoma protein
PathWhiz Pathway	Nucleotide Excision Repair
Reactome	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-1538133:G0 and Early G1
	Activation of ATR in response to replication stress
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	Processing of DNA double-strand break ends
	G2 Phase
	Orc1 removal from chromatin
	Cyclin E associated events during G1/S transition
	Cyclin A/B1 associated events during G2/M transition
	p53-Dependent G1 DNA Damage Response
	Cyclin A:Cdk2-associated events at S phase entry
	Meiotic recombination
	Factors involved in megakaryocyte development and platelet productionR-HSA-113510:E2F mediated regulation of DNA replication
	G0 and Early G1
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
	HDR through Homologous Recombination (HRR)
	Dual Incision in GG-NER
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	G1/S-Specific Transcription
	Cyclin A:Cdk2-associated events at S phase entryR-HSA-113510:E2F mediated regulation of DNA replication
WikiPathways	Cardiac Hypertrophic Response
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Host Interactions of HIV factors
	HIV Life Cycle
	IL-9 Signaling Pathway
	RNA Polymerase II Transcription
	MicroRNAs in cardiomyocyte hypertrophyWP707:DNA Damage Response
	ID signaling pathway
	DNA Replication
	G1 to S cell cycle control
	M/G1 Transition
	S Phase
	Meiotic Recombination
	Aryl Hydrocarbon Receptor
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Synthesis of DNA
	Regulation of DNA replication
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP615:Senescence and Autophagy in Cancer
	Mismatch repair
	EGF/EGFR Signaling Pathway
	Nifedipine Activity
	Primary Focal Segmental Glomerulosclerosis FSGS
	Nucleotide Excision Repair
	Telomere Maintenance
	Base Excision RepairWP707:DNA Damage Response
	Parkinsons Disease Pathway
	Parkin-Ubiquitin Proteasomal System pathway
	miRNAs involved in DNA damage response
	miRNA Regulation of DNA Damage Response
	Androgen receptor signaling pathway
References
Ref 528490	J Med Chem. 2006 Nov 2;49(22):6500-9.4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Ref 528490	J Med Chem. 2006 Nov 2;49(22):6500-9.4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.

Drug Information