Drug Information

Drug General Information
Drug ID
D03CRT
Former ID
DIB019193
Drug Name
compound 10
Synonyms
Aurora A inhibitor I; 2,4-Bisanilinopyrimidine, 10
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530097]
Formula
C31H31ClFN7O2
InChI
InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)
InChIKey
AKSIZPIFQAYJGF-UHFFFAOYSA-N
PubChem Compound ID
44139710
PubChem Substance ID
85095615, 85240463, 89933648, 99437157, 103596589, 124757258, 125164062, 125748895, 131480877, 135686178, 135686179, 135686200, 135686201, 136348808, 136367424, 136368081, 144115645, 152134488, 152258891, 160647739, 160826427, 162037605, 162202567, 162777849, 163387978, 174006379, 177748916, 180371647, 185975398, 188899551, 202817920, 204366346, 223655647, 223705107, 240403279, 242060194, 252110023, 252158748, 252160286, 252166676, 252214912
Target and Pathway
Target(s) mRNA of Aurora B Target Info Inhibitor [530097]
Aurora protein kinase Target Info Inhibitor [530097]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
WikiPathways Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 530097A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem. 2009 May 28;52(10):3300-7.
Ref 530097A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem. 2009 May 28;52(10):3300-7.