Drug Information

Drug General Information
Drug ID
D07RIQ
Former ID
DNC011272
Drug Name
ADRENOGLOMERULOTROPIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531223]
Formula
C13H16N2O
Canonical SMILES
CC1C2=C(CCN1)C3=C(N2)C=CC(=C3)OC
InChI
1S/C13H16N2O/c1-8-13-10(5-6-14-8)11-7-9(16-2)3-4-12(11)15-13/h3-4,7-8,14-15H,5-6H2,1-2H3
InChIKey
RDUORFDQRFHYBF-UHFFFAOYSA-N
PubChem Compound ID
71028
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Inhibitor [531223]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 531223J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
Ref 531223J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.