Drug Information

Drug General Information
Drug ID
D0B2GS
Former ID
DNC011823
Drug Name
3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533476]
Formula
C10H14N2O2
Canonical SMILES
COC1=CC(=C(C=C1)N)C(=O)CCN
InChI
1S/C10H14N2O2/c1-14-7-2-3-9(12)8(6-7)10(13)4-5-11/h2-3,6H,4-5,11-12H2,1H3
InChIKey
DFZXDYZPSYJYBU-UHFFFAOYSA-N
PubChem Compound ID
44372211
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [533476]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [533476]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [533476]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 533476J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.
Ref 533476J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.