Drug General Information
Drug ID
D0P8BE
Former ID
DNC012055
Drug Name
(3-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534087]
Formula
C17H19N3
Canonical SMILES
CCCN(C1=CC=NC=C1)N2C=C(C3=CC=CC=C32)C
InChI
1S/C17H19N3/c1-3-12-19(15-8-10-18-11-9-15)20-13-14(2)16-6-4-5-7-17(16)20/h4-11,13H,3,12H2,1-2H3
InChIKey
JFXXREWKFGYUCE-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [534087]
Alpha-2A adrenergic receptor Target Info Inhibitor [534087]
Alpha-2B adrenergic receptor Target Info Inhibitor [534087]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 534087J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Ref 534087J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.