Drug Information

Drug General Information
Drug ID
D0X7HD
Former ID
DNC010280
Drug Name
CP-810123
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530609]
Formula
C14H18N4O
Canonical SMILES
CC1=NC2=C(C=C1)OC(=N2)N3CCN4CCC3CC4
InChI
1S/C14H18N4O/c1-10-2-3-12-13(15-10)16-14(19-12)18-9-8-17-6-4-11(18)5-7-17/h2-3,11H,4-9H2,1H3
InChIKey
BSNKYWSMUAGMDO-UHFFFAOYSA-N
PubChem Compound ID
11184481
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Inhibitor [530609]
5-hydroxytryptamine receptor 3A Target Info Inhibitor [530609]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesishsa04726:Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathwayP04375:5HT3 type receptor mediated signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-975298:Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 530609J Med Chem. 2010 Feb 11;53(3):1222-37.Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
Ref 530609J Med Chem. 2010 Feb 11;53(3):1222-37.Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.