Drug Information

Drug General Information
Drug ID
D05VVC
Former ID
DNC012434
Drug Name
7-chloro-3-hydroxyquinazoline-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528453]
Formula
C8H5ClN2O3
Canonical SMILES
C1=CC2=C(C=C1Cl)NC(=O)N(C2=O)O
InChI
1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)
InChIKey
CRTPJJNXJPKDEZ-UHFFFAOYSA-N
PubChem Compound ID
44315786
Target and Pathway
Target(s) Glutamate receptor 1 Target Info Inhibitor [528453]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [528453]
Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [528453]
Glutamate receptor AMPA subtype Target Info Inhibitor [528453]
NMDA receptor subunit NR1 Target Info Inhibitor [528453]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Dopaminergic synapse
Long-term depression
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Nicotine addictionhsa04014:Ras signaling pathway
Rap1 signaling pathway
Alzheimer's disease
Huntington's disease
Cocaine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Calcium signaling pathway
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathwayP00029:Huntington disease
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database EPHB forward signalingerbb4_pathway:ErbB4 signaling events
Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ERR-HSA-3928662:EPHB-mediated forward signaling
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Amyotrophic lateral sclerosis (ALS)
BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 528453J Med Chem. 2006 Oct 5;49(20):6015-26.Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Ref 528453J Med Chem. 2006 Oct 5;49(20):6015-26.Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.