Drug Information

Drug General Information
Drug ID
D05MDY
Former ID
DNC012765
Drug Name
2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534723]
Formula
C10H17NO2
Canonical SMILES
CC1C(=O)CC2(O1)CCN(CC2)C
InChI
1S/C10H17NO2/c1-8-9(12)7-10(13-8)3-5-11(2)6-4-10/h8H,3-7H2,1-2H3
InChIKey
OODDNJQTVFMGCF-UHFFFAOYSA-N
PubChem Compound ID
10176401
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M4 Target Info Inhibitor [534723]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [534723]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [534723]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [534723]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [534723]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
Integration of energy metabolism
GPCRs, Other
References
Ref 534723J Med Chem. 1998 Oct 22;41(22):4181-5.Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.
Ref 534723J Med Chem. 1998 Oct 22;41(22):4181-5.Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.