Drug General Information
Drug ID
D0V1HA
Former ID
DNC013433
Drug Name
N-hydroxy-3-(naphthalen-1-yl)acrylamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528719]
Formula
C13H11NO2
Canonical SMILES
C1=CC=C2C(=C1)C=CC=C2C=CC(=O)NO
InChI
1S/C13H11NO2/c15-13(14-16)9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-9,16H,(H,14,15)/b9-8+
InChIKey
AOXOYUCWJCCUDO-CMDGGOBGSA-N
PubChem Compound ID
Target and Pathway
Target(s) Histone Deacetylase 8 Target Info Inhibitor [528719]
KEGG Pathway Alcoholism
Viral carcinogenesis
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Signaling events mediated by HDAC Class I
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
WikiPathways Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Cell Cycle
References
Ref 528719Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Ref 528719Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.