Drug Information

Drug General Information
Drug ID
D0NF6F
Former ID
DNC001465
Drug Name
Trichostatin A
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [542035]
Formula
C17H22N2O3
InChI
InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChIKey
RTKIYFITIVXBLE-QEQCGCAPSA-N
CAS Number
CAS 58880-19-6
PubChem Compound ID
444732
PubChem Substance ID
639194, 830546, 841099, 7890895, 10299571, 12013760, 14709930, 14710659, 14800564, 16291220, 17425541, 17435668, 24844209, 24900542, 26697088, 26755794, 26755795, 36887655, 46371223, 46391613, 46506659, 48409855, 49975235, 50111294, 53790917, 56310830, 56310866, 56310944, 56311019, 56311051, 56311436, 56311486, 56311582, 56311740, 56311744, 56311808, 56312025, 56312066, 56312070, 56312071, 56312281, 56312376, 56312416, 56312510, 56312643, 56312984, 56312986, 56313049, 56313053, 56313217
ChEBI ID
ChEBI:46024
Target and Pathway
Target(s) Histone deacetylase Target Info Inhibitor [535661], [536509], [537490]
References
Ref 542035(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7005).
Ref 535661Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. Blood. 2003 May 1;101(9):3451-9. Epub 2003 Jan 2.
Ref 536509Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92.
Ref 537490Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Mol Biochem Parasitol. 2009 Jun 16.