Drug Information

Drug General Information
Drug ID
D07LCE
Former ID
DNC004196
Drug Name
1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528087]
Formula
C10H9N3O
Canonical SMILES
C1C2C(=NC(=O)N2)NC3=CC=CC=C31
InChI
1S/C10H9N3O/c14-10-12-8-5-6-3-1-2-4-7(6)11-9(8)13-10/h1-4,8H,5H2,(H2,11,12,13,14)
InChIKey
KVVGGYBLPPGNMA-UHFFFAOYSA-N
PubChem Compound ID
20200511
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [528087]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 528087J Med Chem. 1991 Sep;34(9):2906-16.1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
Ref 528087J Med Chem. 1991 Sep;34(9):2906-16.1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.