Drug General Information
Drug ID
D0EK9T
Former ID
DNC010538
Drug Name
4-Phenyl-benzo[b]thiophene-2-carboxamidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530682]
Formula
C15H12N2S
Canonical SMILES
C1=CC=C(C=C1)C2=C3C=C(SC3=CC=C2)C(=N)N
InChI
1S/C15H12N2S/c16-15(17)14-9-12-11(7-4-8-13(12)18-14)10-5-2-1-3-6-10/h1-9H,(H3,16,17)
InChIKey
HKXOXDHVUZHJFV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Coagulation factor IX Target Info Inhibitor [530682]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 530682J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.
Ref 530682J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.