Drug Information

Drug General Information
Drug ID
D0H8EO
Former ID
DNC010136
Drug Name
3,3-diethyl-1-phenylazetidine-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530511]
Formula
C13H15NO2
Canonical SMILES
CCC1(C(=O)N(C1=O)C2=CC=CC=C2)CC
InChI
1S/C13H15NO2/c1-3-13(4-2)11(15)14(12(13)16)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
InChIKey
KDXSTYUPRNLDGW-UHFFFAOYSA-N
PubChem Compound ID
139973
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [530511]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.