Drug Information

Drug General Information
Drug ID
D0UD9H
Former ID
DNC009072
Drug Name
AM-281
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542433]
Formula
C21H19Cl2IN4O2
InChI
InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
InChIKey
AJFFBPZYXRNAIC-UHFFFAOYSA-N
PubChem Compound ID
4302962
PubChem Substance ID
6319092, 9633964, 11113926, 14963226, 24724384, 29215036, 35590691, 57356906, 78939620, 85229929, 85788638, 91702814, 103632291, 104114218, 104231684, 104253241, 112831392, 126602131, 127414551, 134346277, 135649928, 135697593, 136345205, 141403573, 162022968, 162248550, 163124178, 204380364, 227720041, 241050887, 241182141, 241375224, 250130890, 251962113, 251971031, 252159963, 252214708, 252265250
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [530009]
Cannabinoid receptor 1 Target Info Inhibitor [530009]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 542433(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 741).
Ref 530009Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. Epub 2009 Feb 21.Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists.