Drug Information

Drug General Information
Drug ID
D0YN1E
Former ID
DNC003635
Drug Name
3,6-Di-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526462]
Formula
C16H11N5
Canonical SMILES
C1=CN=CC=C1C2=CN3C(=C(C=N3)C4=CC=NC=C4)N=C2
InChI
1S/C16H11N5/c1-5-17-6-2-12(1)14-9-19-16-15(10-20-21(16)11-14)13-3-7-18-8-4-13/h1-11H
InChIKey
ZLISHOMLHVNDJG-UHFFFAOYSA-N
PubChem Compound ID
5329454
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 2 Target Info Inhibitor [526462]
mRNA of VEGFR1 Target Info Inhibitor [526421]
Vascular endothelial growth factor receptor 3 Target Info Inhibitor [526421]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
S1P3 pathway
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2vegf_vegfr_pathway:VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endothelium
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
AngiogenesisWP1919:Signaling by VEGF
References
Ref 526462Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41.Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.
Ref 526421Bioorg Med Chem Lett. 2002 Oct 7;12(19):2767-70.Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors.
Ref 526462Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41.Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.