Drug Information

Drug General Information
Drug ID
D0A6GK
Former ID
DNC004347
Drug Name
(2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534315]
Formula
C9H7Cl2N3
Canonical SMILES
C1=CC(=C(C(=C1)Cl)NC2=NC=CN2)Cl
InChI
1S/C9H7Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-5H,(H2,12,13,14)
InChIKey
JMIQFISPBOHMQG-UHFFFAOYSA-N
PubChem Compound ID
10489502
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [534315]
Alpha-2C adrenergic receptor Target Info Inhibitor [534315]
Alpha-1D adrenergic receptor Target Info Inhibitor [534315]
Alpha-1B adrenergic receptor Target Info Inhibitor [534315]
Alpha-2A adrenergic receptor Target Info Inhibitor [534315]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Salivary secretionhsa04020:Calcium signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR downstream signalingWP58:Monoamine GPCRs
GPCRs, OtherWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
References
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.