Drug Information

Drug General Information
Drug ID
D03LPH
Former ID
DNC011609
Drug Name
TRYPTOLINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526918]
Formula
C11H12N2
Canonical SMILES
C1CNCC2=C1C3=CC=CC=C3N2
InChI
1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2
InChIKey
CFTOTSJVQRFXOF-UHFFFAOYSA-N
PubChem Compound ID
107838
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Inhibitor [526918]
Amine oxidase [flavin-containing] B Target Info Inhibitor [526918]
Alpha-2B adrenergic receptor Target Info Inhibitor [526918]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [526899]
Amine oxidase [flavin-containing] A Target Info Inhibitor [526918]
Alpha-2C adrenergic receptor Target Info Inhibitor [526918]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation II
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa00260:Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Inflammatory mediator regulation of TRP channelshsa00260:Glycine, serine and threonine metabolism
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-181430:Norepinephrine Neurotransmitter Release CycleR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP465:Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compoundsWP58:Monoamine GPCRs
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, OtherWP706:SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter ActivityWP58:Monoamine GPCRs
References
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 526899Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5.Binding of beta-carbolines at 5-HT(2) serotonin receptors.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.