Drug Information

Drug General Information
Drug ID
D0N6ES
Former ID
DNC008115
Drug Name
KN-62
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541267]
Formula
C38H35N5O6S2
InChI
InChI=1S/C38H35N5O6S2/c1-41(51(45,46)37-12-6-8-30-27-40-20-18-34(30)37)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)47-49-50-48-36-11-5-7-29-26-39-19-17-33(29)36/h2-20,26-27,35H,21-25H2,1H3
InChIKey
BLLBARDQJSOSJD-UHFFFAOYSA-N
PubChem Compound ID
16760529
PubChem Substance ID
26759023, 99302610, 163687825, 175607494, 178102623
Target and Pathway
Target(s) Ribosomal protein S6 kinase Target Info Inhibitor [525872]
Serine/threonine-protein kinase Chk1 Target Info Inhibitor [525872]
Rho-associated protein kinase 1 Target Info Inhibitor [525872]
MAP kinase p38 Target Info Inhibitor [525872]
Mitogen-activated protein kinase 1 Target Info Inhibitor [525872]
Serine/threonine-protein kinase Sgk1 Target Info Inhibitor [525872]
Protein kinase C, alpha type Target Info Inhibitor [525872]
Mitogen-activated protein kinase 11 Target Info Inhibitor [525872]
P2X purinoceptor 7 Target Info Inhibitor [530421]
Mitogen-activated protein kinase 14 Target Info Inhibitor [525872]
RAC serine/threonine-protein kinase Target Info Inhibitor [525872]
Lck tyrosine kinase Target Info Inhibitor [525872]
Mitogen-activated protein kinase 8 Target Info Inhibitor [525872]
KEGG Pathway ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
TGF-beta signaling pathway
Fc gamma R-mediated phagocytosis
Insulin signaling pathway
Proteoglycans in cancer
Acute myeloid leukemia
Choline metabolism in cancerhsa04110:Cell cycle
p53 signaling pathway
HTLV-I infection
Viral carcinogenesishsa04022:cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Vascular smooth muscle contraction
Axon guidance
Focal adhesion
Platelet activation
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pathways in cancer
MicroRNAs in cancerhsa04010:MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
Ras signaling pathway
cGMP-PKG signaling pathway
Dorso-ventral axis formation
Adherens junction
Gap junction
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Estrogen signaling pathway
Melanogenesis
Thyroid hormone signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Hepatitis B
Viral carcinogenesis
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04068:FoxO signaling pathway
Aldosterone-regulated sodium reabsorptionhsa04010:MAPK signaling pathway
Calcium signaling pathway
Phosphatidylinositol signaling system
Wnt signaling pathway
Tight junction
GABAergic synapse
Insulin secretion
Thyroid hormone synthesis
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Proteoglycans in cancerhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04010:MAPK signaling pathway
Apoptosis
Jak-STAT signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Non-alcoholic fatty liver disease (NAFLD)
Carbohydrate digestion and absorption
Measles
Small cell lung cancer
Choline metabolism in cancerhsa04064:NF-kappa B signaling pathway
Primary immunodeficiencyhsa04010:MAPK signaling pathway
Protein processing in endoplasmic reticulum
Herpes simplex infection
Choline metabolism in cancer
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
TCR Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
PDGF signaling pathway
PI3 kinase pathway
p53 pathway by glucose deprivation
CCKR signaling map STP00016:Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
Endothelin signaling pathway
Interleukin signaling pathway
T cell activation
VEGF signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
Toll receptor signaling pathway
p38 MAPK pathway
CCKR signaling map STP00005:Angiogenesis
Huntington disease
Hypoxia response via HIF activation
Insulin/IGF pathway-protein kinase B signaling cascade
p53 pathway
CCKR signaling map STP00049:Parkinson disease
T cell activationP00003:Alzheimer disease-amyloid secretase pathway
FAS signaling pathway
Integrin signalling pathway
CCKR signaling map ST
Pathway Interaction Database Insulin Pathway
IL4-mediated signaling events
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
Regulation of Telomerase
mTOR signaling pathway
IGF1 pathway
IL2 signaling events mediated by PI3K
Integrins in angiogenesis
RXR and RAR heterodimerization with other nuclear receptor
Signaling events mediated by Stem cell factor receptor (c-Kit)
a6b1 and a6b4 Integrin signaling
TGF-beta receptor signalingfanconi_pathway:Fanconi anemia pathway
p73 transcription factor network
ATR signaling pathway
Circadian rhythm pathway
p53 pathwayprlsignalingeventspathway:Signaling events mediated by PRL
RhoA signaling pathway
Noncanonical Wnt signaling pathway
EPHB forward signaling
Thromboxane A2 receptor signaling
PAR4-mediated thrombin signaling events
amb2 Integrin signaling
EPHA forward signaling
Stabilization and expansion of the E-cadherin adherens junction
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
N-cadherin signaling eventsrhoa_pathway:RhoA signaling pathway
Signaling mediated by p38-gamma and p38-deltafcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
Signaling events mediated by PRL
ErbB4 signaling events
GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
S1P3 pathway
Osteopontin-mediated events
S1P4 pathway
Presenilin action in Notch and Wnt signaling
TRAIL signaling pathway
Signaling events regulated by Ret tyrosine kinase
S1P1 pathway
Netrin-mediated signaling events
Glucocorticoid receptor regulatory network
Arf6 downstream pathway
Class IB PI3K non-lipid kinase events
IL2-mediated signaling events
EGF receptor (ErbB1) signaling pathway
Ras signaling in the CD4+ TCR pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
ATF-2 transcription factor network
ErbB2/ErbB3 signaling events
BMP receptor signaling
ALK1 signaling events
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-1-mediated signaling events
Retinoic acid receptors-mediated signaling
Nongenotropic Androgen signaling
CXCR3-mediated signaling events
VEGFR1 specific signals
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Syndecan-2-mediated signaling events
Cellular roles of Anthrax toxin
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na&#xef
VEGFR3 signaling in lymphatic endothelium
Alpha-synuclein signaling
FGF signaling pathway
Signaling events mediated by focal adhesion kinaseinsulin_pathway:Insulin Pathway
FoxO family signaling
Class I PI3K signaling eventsendothelinpathway:Endothelins
TCR signaling in na&#xef
Canonical NF-kappaB pathway
TCR signaling in na&#xef
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Syndecan-4-mediated signaling events
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
p73 transcription factor network
p38 MAPK signaling pathway
Plasma membrane estrogen receptor signaling
CD40/CD40L signaling
Regulation of p38-alpha and p38-beta
FAS (CD95) signaling pathway
Rapid glucocorticoid signaling
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Signaling mediated by p38-alpha and p38-beta
Regulation of retinoblastoma proteinendothelinpathway:Endothelins
Atypical NF-kappaB pathway
IL12-mediated signaling events
Regulation of Androgen receptor activity
EPO signaling pathway
p53 pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
LPA receptor mediated events
Signaling events mediated by PTP1B
Coregulation of Androgen receptor activity
Reelin signaling pathway
Integrin-linked kinase signaling
FOXA2 and FOXA3 transcription factor networks
CXCR4-mediated signaling events
p75(NTR)-mediated signaling
E-cadherin signaling in the nascent adherens junction
E-cadherin signaling in keratinocytes
Nephrin/Neph1 signaling in the kidney podocyte
Signaling events mediated by the Hedgehog family
Hedgehog signaling events mediated by Gli proteins
Caspase Cascade in Apoptosis
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
HIF-1-alpha transcription factor network
Trk receptor signaling mediated by PI3K and PLC-gamma
FGF signaling pathwaynfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
SHP2 signaling
Class I PI3K signaling events
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
IL1-mediated signaling events
JNK signaling in the CD4+ TCR pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
N-cadherin signaling events
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4
PathWhiz Pathway Leucine Stimulation on Insulin SignalingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin SignallingPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Insulin Signalling
Reactome mTORC1-mediated signallingR-HSA-176187:Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-111465:Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKsR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
CDO in myogenesis
DSCAM interactions
VEGFA-VEGFR2 PathwayR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signalingR-HSA-2672351:Stimuli-sensing channelsR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+R-HSA-168638:NOD1/2 Signaling Pathway
activated TAK1 mediates p38 MAPK activation
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-844456:The NLRP3 inflammasomeR-HSA-168638:NOD1/2 Signaling Pathway
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-111447:Activation of BAD and translocation to mitochondria
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-114604:GPVI-mediated activation cascade
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent Vav1 pathway
PD-1 signaling
Interleukin-2 signalingR-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
WikiPathways ErbB Signaling Pathway
Interferon type I signaling pathways
G13 Signaling Pathway
IL-2 Signaling Pathway
Insulin Signaling
Cytoplasmic Ribosomal Proteins
EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
IL-6 signaling pathway
Kit receptor signaling pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
BDNF signaling pathway
Interleukin-11 Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
TSH signaling pathway
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
IL-5 Signaling PathwayWP707:DNA Damage Response
Signaling by SCF-KIT
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP524:G13 Signaling Pathway
Regulation of Actin Cytoskeleton
TGF beta Signaling Pathway
Focal Adhesion
JAK/STAT
AGE/RAGE pathway
Pathogenic Escherichia coli infection
Regulation of Microtubule Cytoskeleton
Semaphorin interactions
Integrin-mediated Cell Adhesion
GPCR downstream signaling
Apoptotic execution phase
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathwayWP75:Toll-like receptor signaling pathway
MAPK Cascade
MAPK Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Signal Transduction of S1P Receptor
Parkinsons Disease Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
NGF signalling via TRKA from the plasma membrane
Myogenesis
DSCAM interactions
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Serotonin HTR1 Group and FOS Pathway
Vitamin A and Carotenoid Metabolism
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
Hypothetical Network for Drug Addiction
Senescence and Autophagy in Cancer
EPO Receptor Signaling
Signaling of Hepatocyte Growth Factor Receptor
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
IL-3 Signaling Pathway
Bladder Cancer
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Structural Pathway of Interleukin 1 (IL-1)
Genes and (Common) Pathways Underlying Drug Addiction
EBV LMP1 signaling
Nifedipine Activity
Aryl Hydrocarbon Receptor
PDGF Pathway
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
Signaling Pathways in Glioblastoma
TSLP Signaling Pathway
IL-9 Signaling Pathway
Endothelin Pathways
IL17 signaling pathway
Alzheimers Disease
IL-7 Signaling Pathway
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
Opioid Signalling
IL-1 signaling pathway
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by FGFR
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Type II diabetes mellitus
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling PathwayWP481:Insulin Signaling
Iron uptake and transport
FSH signaling pathwayWP673:ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Wnt Signaling Pathway Netpath
G Protein Signaling Pathways
Transcriptional activation by NRF2
Myometrial Relaxation and Contraction Pathways
Human Complement System
Syndecan interactions
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
miRs in Muscle Cell Differentiation
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP2763:Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysWP75:Toll-like receptor signaling pathway
Monoamine Transport
Oxidative Stress
p38 MAPK Signaling Pathway
Amyotrophic lateral sclerosis (ALS)
Cardiac Progenitor Differentiation
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Signal amplification
Platelet homeostasis
Notch Signaling Pathway
Endochondral Ossification
Copper homeostasis
Extracellular vesicle-mediated signaling in recipient cells
Translocation of GLUT4 to the Plasma Membrane
PIP3 activates AKT signaling
Primary Focal Segmental Glomerulosclerosis FSGS
Apoptosis
SREBP signalling
Metabolism of nitric oxide
TFs Regulate miRNAs related to cardiac hypertrophy
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP61:Notch Signaling Pathway
Inflammatory Response Pathway
DAP12 interactions
Host Interactions of HIV factors
TCR signaling
Costimulation by the CD28 familyWP75:Toll-like receptor signaling pathway
FAS pathway and Stress induction of HSP regulation
NLR Proteins
Nanoparticle triggered regulated necrosis
Signalling by NGF
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
Osteoclast Signaling
References
Ref 541267(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6001).
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 530421Bioorg Med Chem Lett. 2009 Nov 1;19(21):6053-8. Epub 2009 Sep 17.Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists.