Drug Information

Drug General Information
Drug ID
D0A4NO
Former ID
DNC014008
Drug Name
L-162313
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540558]
Formula
C30H38N4O4S2
InChI
InChI=1S/C30H38N4O4S2/c1-7-9-14-38-30(35)33-40(36,37)29-25(17-24(39-29)15-19(3)4)23-12-10-22(11-13-23)18-34-26(8-2)32-27-20(5)16-21(6)31-28(27)34/h10-13,16-17,19H,7-9,14-15,18H2,1-6H3,(H,33,35)
InChIKey
RINPELQWLUGERM-UHFFFAOYSA-N
PubChem Compound ID
6603900
PubChem Substance ID
11111368, 11646401, 14911428, 17405258, 24278791, 43223692, 47720610, 50106511, 50106512, 53777803, 57264287, 80565157, 85231107, 90340748, 92304142, 103216664, 103979543, 114637026, 121361659, 124749924, 124880528, 129134295, 134351213, 135298187, 162247851, 163564651, 178100764, 234569739, 242177890, 252341892, 252559370
Target and Pathway
Target(s) Type-2 angiotensin II receptor Target Info Inhibitor [530937]
Type-1 angiotensin II receptor Target Info Inhibitor [529578]
KEGG Pathway Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Renin-angiotensin systemhsa04020:Calcium signaling pathway
cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP554:ACE Inhibitor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Allograft Rejection
GPCR downstream signaling
References
Ref 540558(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3936).
Ref 529578Bioorg Med Chem. 2008 Jul 15;16(14):6841-9. Epub 2008 Jul 1.Selective angiotensin II AT2 receptor agonists: Benzamide structure-activity relationships.
Ref 530937Bioorg Med Chem. 2010 Jun 15;18(12):4570-90. Epub 2010 Apr 9.Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition.