TTD | Drug: D0J4NI

Drug General Information
Drug ID	D0J4NI
Former ID	DNC009706
Drug Name	Dihexan-3-yl 5-(hydroxymethyl)isophthalate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530134]
Formula	C21H32O5
Canonical SMILES	CCCC(CC)OC(=O)C1=CC(=CC(=C1)CO)C(=O)OC(CC)CCC
InChI	1S/C21H32O5/c1-5-9-18(7-3)25-20(23)16-11-15(14-22)12-17(13-16)21(24)26-19(8-4)10-6-2/h11-13,18-19,22H,5-10,14H2,1-4H3
InChIKey	ONMFJTSDBZIFTK-UHFFFAOYSA-N
PubChem Compound ID	44186618
Target and Pathway
Target(s)	mRNA of PKC-delta	Target Info	Inhibitor	[530134]
Target(s)	Protein kinase C, alpha type	Target Info	Inhibitor	[530134]
KEGG Pathway	Chemokine signaling pathway
	Vascular smooth muscle contraction
	Tight junction
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Neurotrophin signaling pathway
	Inflammatory mediator regulation of TRP channels
	GnRH signaling pathway
	Estrogen signaling pathway
	Type II diabetes mellitushsa04010:MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	HIF-1 signaling pathway
	Phosphatidylinositol signaling system
	Sphingolipid signaling pathway
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	Adrenergic signaling in cardiomyocytes
	Wnt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Gap junction
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Long-term depression
	Insulin secretion
	Melanogenesis
	Thyroid hormone synthesis
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Aldosterone-regulated sodium reabsorption
	Endocrine and other factor-regulated calcium reabsorption
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
	Amphetamine addiction
	Morphine addiction
	Vibrio cholerae infection
	Pathogenic Escherichia coli infection
	African trypanosomiasis
	Amoebiasis
	Hepatitis B
	Influenza A
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Glioma
	Non-small cell lung cancer
	Choline metabolism in cancer
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	Apoptosis signaling pathway
	B cell activation
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	VEGF signaling pathway
	Wnt signaling pathway
	5HT2 type receptor mediated signaling pathway
	Histamine H1 receptor mediated signaling pathway
	Oxytocin receptor mediated signaling pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
	PDGF signaling pathway
	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	LPA receptor mediated events
	Thromboxane A2 receptor signaling
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	IGF1 pathway
	Ceramide signaling pathway
	IFN-gamma pathway
	ErbB1 downstream signaling
	Syndecan-4-mediated signaling events
	IL6-mediated signaling events
	PDGFR-beta signaling pathway
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
	Syndecan-2-mediated signaling events
	Validated transcriptional targets of TAp63 isoforms
	p53 pathway
	Trk receptor signaling mediated by the MAPK pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
	Alpha-synuclein signalingendothelinpathway:Endothelins
	TCR signaling in na&#xef
	Canonical NF-kappaB pathway
	Signaling events regulated by Ret tyrosine kinase
	TCR signaling in na&#xef
	mTOR signaling pathway
	Ras signaling in the CD4+ TCR pathway
	ATF-2 transcription factor network
	Retinoic acid receptors-mediated signaling
	IL8- and CXCR2-mediated signaling events
	VEGFR1 specific signals
	a6b1 and a6b4 Integrin signaling
	IL8- and CXCR1-mediated signaling events
	Regulation of Ras family activation
	Downstream signaling in na&#xef
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
PathWhiz Pathway	Activation of PKC through G protein coupled receptor
Reactome	Apoptotic cleavage of cellular proteins
	Calmodulin induced events
	Effects of PIP2 hydrolysis
	DAG and IP3 signaling
	Role of phospholipids in phagocytosis
	G alpha (z) signalling events
	HuR (ELAVL1) binds and stabilizes mRNA
	VEGFR2 mediated cell proliferation
	CLEC7A (Dectin-1) signaling
	Interferon gamma signalingR-HSA-111933:Calmodulin induced events
	Disinhibition of SNARE formation
	Regulation of KIT signaling
	EGFR Transactivation by Gastrin
	Inactivation, recovery and regulation of the phototransduction cascade
	Syndecan interactions
	Acetylcholine regulates insulin secretion
	Ca2+ pathway
	Trafficking of GluR2-containing AMPA receptors
	Depolymerisation of the Nuclear Lamina
	WNT5A-dependent internalization of FZD4
	Response to elevated platelet cytosolic Ca2+
WikiPathways	TCR Signaling Pathway
	Type II interferon signaling (IFNG)
	Calcium Regulation in the Cardiac Cell
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	MAPK Signaling Pathway
	IL-6 signaling pathway
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	DAG and IP3 signaling
	Alpha 6 Beta 4 signaling pathway
	BDNF signaling pathway
	Oncostatin M Signaling Pathway
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	B Cell Receptor Signaling Pathway
	Signaling Pathways in Glioblastoma
	miRs in Muscle Cell Differentiation
	Opioid Signalling
	GPCR downstream signaling
	Effects of PIP2 hydrolysis
	Apoptotic execution phase
	Type II diabetes mellitusWP673:ErbB Signaling Pathway
	Wnt Signaling Pathway Netpath
	Kit receptor signaling pathway
	Transcriptional activation by NRF2
	Human Complement System
	Cardiac Hypertrophic Response
	Syndecan interactions
	Signaling by SCF-KIT
	Gastrin-CREB signalling pathway via PKC and MAPK
	T-Cell Receptor and Co-stimulatory Signaling
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Pathogenic Escherichia coli infection
	Endothelin Pathways
	Regulation of Microtubule Cytoskeleton
	FSH signaling pathway
	Response to elevated platelet cytosolic Ca2+
	Integration of energy metabolism
	TOR Signaling
References
Ref 530134	J Med Chem. 2009 Jul 9;52(13):3969-81.Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.
Ref 530134	J Med Chem. 2009 Jul 9;52(13):3969-81.Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.

Drug Information