Drug Information

Drug General Information
Drug ID
D08BSG
Former ID
DNC003690
Drug Name
IODOPROXYFAN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538768]
Formula
C13H15IN2O
InChI
InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
InChIKey
DCQNAFOCXVCDLB-UHFFFAOYSA-N
PubChem Compound ID
132937
PubChem Substance ID
7979633, 14827257, 29310960, 47731205, 48329024, 49846730, 50537305, 53999591, 57344316, 85218026, 103183957, 103947354, 104378585, 126437528, 127715461, 134340895, 135088535, 135650406, 179293864, 229137555
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [526023]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538768(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1253).
Ref 526023Bioorg Med Chem Lett. 2001 Apr 9;11(7):951-4.Different antagonist binding properties of human and rat histamine H3 receptors.