TTD | Drug: D05THD

Drug General Information
Drug ID	D05THD
Former ID	DNC009957
Drug Name	2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530402]
Formula	C19H15NO4S
Canonical SMILES	C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C3=CC=CC=C3C(=O)NO
InChI	1S/C19H15NO4S/c21-19(20-22)17-8-4-5-9-18(17)25(23,24)16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13,22H,(H,20,21)
InChIKey	WQRJSSRVHCJAKB-UHFFFAOYSA-N
PubChem Compound ID	44478925
Target and Pathway
Target(s)	Matrixmetalloproteinase	Target Info	Inhibitor	[530402]
	Matrix metalloproteinase-14	Target Info	Inhibitor	[530402]
	Collagenase 3	Target Info	Inhibitor	[530402]
	MMP-12	Target Info	Inhibitor	[530402]
	MMP-9	Target Info	Inhibitor	[530402]
	72 kDa type IV collagenase	Target Info	Inhibitor	[530402]
	Neutrophil collagenase	Target Info	Inhibitor	[530402]
KEGG Pathway	TNF signaling pathway
	GnRH signaling pathwayhsa04668:TNF signaling pathway
	Leukocyte transendothelial migration
	Estrogen signaling pathway
	Hepatitis B
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Bladder cancerhsa04670:Leukocyte transendothelial migration
	GnRH signaling pathway
	Bladder cancer
NetPath Pathway	IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
	IL5 Signaling PathwayNetPath_5:ID Signaling Pathway
	TWEAK Signaling Pathway
	Leptin Signaling Pathway
	TNFalpha Signaling PathwayNetPath_22:Leptin Signaling Pathway
	TCR Signaling Pathway
	ID Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
	Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
	CCKR signaling map STP00004:Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database	HIF-2-alpha transcription factor network
	Signaling events mediated by focal adhesion kinaseupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Validated targets of C-MYC transcriptional activation
	CXCR4-mediated signaling events
	amb2 Integrin signaling
	Syndecan-4-mediated signaling events
	AP-1 transcription factor network
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Syndecan-1-mediated signaling events
	Regulation of nuclear beta catenin signaling and target gene transcription
	FGF signaling pathwaylysophospholipid_pathway:LPA receptor mediated events
	Angiopoietin receptor Tie2-mediated signaling
	Direct p53 effectors
	ATF-2 transcription factor network
	FOXM1 transcription factor network
	Syndecan-2-mediated signaling events
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix MetalloproteinasesR-HSA-1442490:Collagen degradation
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
	Degradation of the extracellular matrixR-HSA-1442490:Collagen degradation
	Assembly of collagen fibrils and other multimeric structures
	EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WikiPathways	Senescence and Autophagy in Cancer
	Activation of Matrix Metalloproteinases
	Degradation of collagen
	AGE/RAGE pathway
	Matrix MetalloproteinasesWP474:Endochondral Ossification
	Oncostatin M Signaling Pathway
	Matrix MetalloproteinasesWP366:TGF beta Signaling Pathway
	IL1 and megakaryotyces in obesity
	Mammary gland development pathway - Involution (Stage 4 of 4)
	Spinal Cord Injury
	TWEAK Signaling Pathway
	Angiogenesis
	Osteopontin Signaling
	Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
	Matrix Metalloproteinases
References
Ref 530402	J Med Chem. 2009 Oct 22;52(20):6347-61.Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Ref 530402	J Med Chem. 2009 Oct 22;52(20):6347-61.Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.

Drug Information