Drug Information

Drug General Information
Drug ID
D0S7IE
Former ID
DNC006663
Drug Name
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528237]
Formula
C14H12N4O
Canonical SMILES
CC(=O)NC1=NC(=C(C(=C1)N)C#N)C2=CC=CC=C2
InChI
1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19)
InChIKey
GTMGQYXCPKUZAD-UHFFFAOYSA-N
PubChem Compound ID
11658882
Target and Pathway
Target(s) mRNA of human Jun-N-terminal kinase-2 (JNK2) Target Info Inhibitor [528237]
Cell division protein kinase 2 Target Info Inhibitor [528237]
Mitogen-activated protein kinase 10 Target Info Inhibitor [528237]
Mitogen-activated protein kinase 8 Target Info Inhibitor [528237]
mRNA of Inhibitor-kappa B Kinase-alpha Target Info Inhibitor [528237]
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancerhsa04068:FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Measles
Viral carcinogenesis
Prostate cancer
Small cell lung cancerhsa04010:MAPK signaling pathway
Choline metabolism in cancerhsa04010:MAPK signaling pathway
HTLV-I infection
Chemokine signaling pathway
NF-kappa B signaling pathway
Apoptosis
Cytosolic DNA-sensing pathway
B cell receptor signaling pathway
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
NetPath Pathway TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
TNFalpha Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
B cell activation
FAS signaling pathway
Huntington disease
Integrin signalling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
T cell activation
Toll receptor signaling pathway
Ras Pathway
CCKR signaling map STP00059:p53 pathway
p53 pathway feedback loops 2P00003:Alzheimer disease-amyloid secretase pathway
EGF receptor signaling pathway
FGF signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
PDGF signaling pathway
CCKR signaling map STP00006:Apoptosis signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database Noncanonical Wnt signaling pathway
CD40/CD40L signaling
CDC42 signaling events
FAS (CD95) signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
Rapid glucocorticoid signaling
FoxO family signaling
p75(NTR)-mediated signaling
ErbB1 downstream signaling
ATF-2 transcription factor network
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocyte
p53 pathway
Downstream signaling in na&#xef
RAC1 signaling pathway
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4smad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by PRL
p73 transcription factor network
E2F transcription factor network
ATR signaling pathway
mTOR signaling pathway
FOXM1 transcription factor network
BARD1 signaling events
Regulation of retinoblastoma proteinwnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
Nephrin/Neph1 signaling in the kidney podocytefcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
RhoA signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
Reelin signaling pathway
TRAIL signaling pathway
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
IL1-mediated signaling events
Ceramide signaling pathway
Regulation of Androgen receptor activity
JNK signaling in the CD4+ TCR pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Retinoic acid receptors-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Syndecan-2-mediated signaling events
Ephrin B reverse signaling
N-cadherin signaling events
S1P2 pathway
IL12 signaling mediated by STAT4fcer1pathway:Fc-epsilon receptor I signaling in mast cells
TCR signaling in na&#xef
Canonical NF-kappaB pathway
Alternative NF-kappaB pathway
TCR signaling in na&#xef
TNF receptor signaling pathway
Validated nuclear estrogen receptor alpha network
Class I PI3K signaling events mediated by Akt
Validated transcriptional targets of TAp63 isoforms
Endogenous TLR signaling
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factorsR-HSA-1538133:G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
G2 Phase
Orc1 removal from chromatin
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet productionR-HSA-2559580:Oxidative Stress Induced Senescence
Activation of the AP-1 family of transcription factorsR-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
DSCAM interactions
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-1169091:Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
TGF Beta Signaling Pathway
Insulin Signaling
EGF/EGFR Signaling Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
TGF beta Signaling Pathway
Wnt Signaling Pathway Netpath
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
JAK/STAT
ATM Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
Regulation of toll-like receptor signaling pathwayWP707:DNA Damage Response
ID signaling pathway
DNA Replication
G1 to S cell cycle control
M/G1 Transition
S Phase
Meiotic Recombination
Aryl Hydrocarbon Receptor
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Prostate Cancer
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Synthesis of DNA
Regulation of DNA replication
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Factors involved in megakaryocyte development and platelet production
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP75:Toll-like receptor signaling pathway
G13 Signaling Pathway
MAPK Cascade
Oxidative Stress
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
Apoptosis
Integrin-mediated Cell Adhesion
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
ErbB Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Transcriptional activation by NRF2
NLR Proteins
IL-3 Signaling Pathway
Cardiac Hypertrophic Response
EBV LMP1 signaling
PDGF Pathway
Nanoparticle triggered regulated necrosis
Leptin signaling pathway
Signalling by NGF
Intrinsic Pathway for Apoptosis
DSCAM interactions
Apoptosis Modulation and Signaling
Type II diabetes mellitus
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteoclast SignalingWP2526:PDGF Pathway
References
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.