Drug Information

Drug General Information
Drug ID
D0F6YB
Former ID
DNC014418
Drug Name
3-cyano-5-fluoro-N-phenylbenzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531010]
Formula
C14H9FN2O
Canonical SMILES
C1=CC=C(C=C1)NC(=O)C2=CC(=CC(=C2)C#N)F
InChI
1S/C14H9FN2O/c15-12-7-10(9-16)6-11(8-12)14(18)17-13-4-2-1-3-5-13/h1-8H,(H,17,18)
InChIKey
MCCCAUONCIKYRV-UHFFFAOYSA-N
PubChem Compound ID
49862431
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [531010]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 531010Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.
Ref 531010Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. Epub 2010 Jun 15.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds withCNS exposure in rats.