TTD | Drug: D04ZGF

Drug General Information
Drug ID	D04ZGF
Former ID	DNC012677
Drug Name	5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525760]
Formula	C14H15N3
Canonical SMILES	C1CC2=C(C=CC=N2)C(=C1)CCN3C=CN=C3
InChI	1S/C14H15N3/c1-3-12(6-9-17-10-8-15-11-17)13-4-2-7-16-14(13)5-1/h2-4,7-8,10-11H,1,5-6,9H2
InChIKey	DJMSMHXCSIBVSA-UHFFFAOYSA-N
PubChem Compound ID	10561174
Target and Pathway
Target(s)	Prostaglandin G/H synthase 1	Target Info	Inhibitor	[525760]
	Prostaglandin G/H synthase 2	Target Info	Inhibitor	[525760]
	Thromboxane-A synthase	Target Info	Inhibitor	[525760]
BioCyc Pathway	C20 prostanoid biosynthesisPWY66-393:Aspirin-triggered lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	C20 prostanoid biosynthesis
	Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
	Serotonergic synapsehsa00590:Arachidonic acid metabolism
	NF-kappa B signaling pathway
	VEGF signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Serotonergic synapse
	Ovarian steroidogenesis
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Leishmaniasis
	Pathways in cancer
	Chemical carcinogenesis
	MicroRNAs in cancer
	Small cell lung cancerhsa00590:Arachidonic acid metabolism
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling Pathway
	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL5 Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathwayP00019:Endothelin signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Toll receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	S1P1 pathway
	C-MYB transcription factor network
	Signaling mediated by p38-alpha and p38-beta
	Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway	Arachidonic Acid MetabolismPW000044:Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
	Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
References
Ref 525760	J Med Chem. 2000 May 4;43(9):1841-51.1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.
Ref 525760	J Med Chem. 2000 May 4;43(9):1841-51.1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.

Drug Information