Drug Information

Drug General Information
Drug ID
D0O3BL
Former ID
DNC012750
Drug Name
RS-14491
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534389]
Formula
C19H13ClN4O
Canonical SMILES
C1=CC(=CC(=C1)Cl)C2=NN(C(=O)C3=C2N=CC=C3)CC4=CC=NC=C4
InChI
1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)17-18-16(5-2-8-22-18)19(25)24(23-17)12-13-6-9-21-10-7-13/h1-11H,12H2
InChIKey
COLQUUDNEIJASV-UHFFFAOYSA-N
PubChem Compound ID
19700663
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [534389]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [534389]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 534389J Med Chem. 1997 May 9;40(10):1417-21.Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors.
Ref 534389J Med Chem. 1997 May 9;40(10):1417-21.Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors.