Drug Information

Drug General Information
Drug ID
D0HO7I
Former ID
DNC013484
Drug Name
ANONAINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528616]
Formula
C17H15NO2
Canonical SMILES
C1CNC2CC3=CC=CC=C3C4=C2C1=CC5=C4OCO5
InChI
1S/C17H15NO2/c1-2-4-12-10(3-1)7-13-15-11(5-6-18-13)8-14-17(16(12)15)20-9-19-14/h1-4,8,13,18H,5-7,9H2/t13-/m1/s1
InChIKey
VZTUKBKUWSHDFM-CYBMUJFWSA-N
PubChem Compound ID
160597
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [528616]
Sodium-dependent dopamine transporter Target Info Inhibitor [551362]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04728:Dopaminergic synapse
Amphetamine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Pathway Interaction Database Alpha-synuclein signaling
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP727:Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 528616J Med Chem. 2007 Jan 25;50(2):171-81.Advances in development of dopaminergic aporphinoids.
Ref 528616J Med Chem. 2007 Jan 25;50(2):171-81.Advances in development of dopaminergic aporphinoids.
Ref 551362Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.