Drug General Information
Drug ID
D05AJZ
Former ID
DNC006456
Drug Name
6-bromo-1-methyl-3-(pyridin-4-yl)-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528040]
Formula
C14H11BrN2
Canonical SMILES
CN1C=C(C2=C1C=C(C=C2)Br)C3=CC=NC=C3
InChI
1S/C14H11BrN2/c1-17-9-13(10-4-6-16-7-5-10)12-3-2-11(15)8-14(12)17/h2-9H,1H3
InChIKey
FSWMKLCDACNCRN-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase 2 Target Info Inhibitor [528040]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides de novo biosynthesis
Superpathway of purine nucleotide salvage
Purine nucleotides de novo biosynthesis
Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway Purine metabolism
Drug metabolism - other enzymes
Metabolic pathways
PANTHER Pathway De novo purine biosynthesis
Reactome Purine ribonucleoside monophosphate biosynthesis
References
Ref 528040Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.
Ref 528040Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.