Drug Information

Drug General Information
Drug ID
D0LG8A
Former ID
DNC007814
Drug Name
1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529013]
Formula
C9H12F5NS
Canonical SMILES
CC(CC1=CC(=CC=C1)S(F)(F)(F)(F)F)N
InChI
1S/C9H12F5NS/c1-7(15)5-8-3-2-4-9(6-8)16(10,11,12,13)14/h2-4,6-7H,5,15H2,1H3
InChIKey
YGBSUVPUXAMOTQ-UHFFFAOYSA-N
PubChem Compound ID
23643874
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Inhibitor [529013]
5-hydroxytryptamine 6 receptor Target Info Inhibitor [529013]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [529013]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [529013]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [529013]
5-hydroxytryptamine 7 receptor Target Info Inhibitor [529013]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [529013]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Serotonergic synapsehsa04024:cAMP signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04014:Ras signaling pathway
Calcium signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and SerotoninPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 529013Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. Epub 2007 Aug 15.The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine.
Ref 529013Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. Epub 2007 Aug 15.The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine.