Drug General Information
Drug ID
D02LXJ
Former ID
DNC007083
Drug Name
3-(2-cinnamylphenyl)acrylic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528393]
Formula
C18H16O2
Canonical SMILES
C1=CC=C(C=C1)C=CCC2=CC=CC=C2C=CC(=O)O
InChI
1S/C18H16O2/c19-18(20)14-13-17-11-5-4-10-16(17)12-6-9-15-7-2-1-3-8-15/h1-11,13-14H,12H2,(H,19,20)/b9-6+,14-13+
InChIKey
LDBYEQVSQBZSEH-BDXQXIFWSA-N
PubChem Compound ID
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Inhibitor [528393]
Prostaglandin E2 receptor EP3 subtype Target Info Inhibitor [528393]
Prostaglandin E2 receptor, EP4 subtype Target Info Inhibitor [528393]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Pathways in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Vitamin D Receptor Pathway
GPCR downstream signaling
References
Ref 528393Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. Epub 2006 Aug 22.Comparison between two classes of selective EP(3) antagonists and their biological activities.
Ref 528393Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. Epub 2006 Aug 22.Comparison between two classes of selective EP(3) antagonists and their biological activities.