TTD | Drug: D0U0ZE

Drug General Information
Drug ID	D0U0ZE
Former ID	DNC006330
Drug Name	3-hydroxy-8,10-dimethyl-6H-benzo[c]chromen-6-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527966]
Formula	C15H12O3
Canonical SMILES	CC1=CC(=C2C3=C(C=C(C=C3)O)OC(=O)C2=C1)C
InChI	1S/C15H12O3/c1-8-5-9(2)14-11-4-3-10(16)7-13(11)18-15(17)12(14)6-8/h3-7,16H,1-2H3
InChIKey	LTZNXKCOWADUFT-UHFFFAOYSA-N
PubChem Compound ID	44408769
Target and Pathway
Target(s)	Estrogen receptor	Target Info	Inhibitor	[527966]
Target(s)	Estrogen receptor beta	Target Info	Inhibitor	[527966]
KEGG Pathway	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Endocrine and other factor-regulated calcium reabsorption
	Proteoglycans in cancerhsa04915:Estrogen signaling pathway
NetPath Pathway	FSH Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class II
	Plasma membrane estrogen receptor signaling
	LKB1 signaling events
	Regulation of Telomerase
	ATF-2 transcription factor network
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Validated nuclear estrogen receptor alpha network
	Signaling mediated by p38-alpha and p38-beta
	FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated nuclear estrogen receptor beta network
Reactome	Nuclear signaling by ERBB4
Reactome	Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways	Estrogen signaling pathway
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	Signaling by ERBB4
	JAK/STAT
	Integrated Pancreatic Cancer Pathway
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Integrated Breast Cancer Pathway
	Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Nuclear Receptors
References
Ref 527966	Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. Epub 2006 Jan 18.6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.
Ref 527966	Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. Epub 2006 Jan 18.6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.

Drug Information