Drug Information

Drug General Information
Drug ID
D07ANY
Former ID
DNC004181
Drug Name
1H-1,2,3-benzotriazol-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526196]
Formula
C6H6N4
Canonical SMILES
C1=CC=C2C(=C1)N=NN2N
InChI
1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
InChIKey
JCXKHYLLVKZPKE-UHFFFAOYSA-N
PubChem Compound ID
1367
Target and Pathway
Target(s) Cytochrome P450 3A4 Target Info Inhibitor [526196]
Cytochrome P450 2D6 Target Info Inhibitor [526196]
KEGG Pathway Steroid hormone biosynthesis
Linoleic acid metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Bile secretion
Chemical carcinogenesishsa00980:Metabolism of xenobiotics by cytochrome P450
Serotonergic synapse
PathWhiz Pathway Caffeine Metabolism
Retinol Metabolism
Reactome Xenobiotics
Aflatoxin activation and detoxificationR-HSA-211981:Xenobiotics
WikiPathways Metapathway biotransformation
Aflatoxin B1 metabolism
Estrogen metabolism
Benzo(a)pyrene metabolism
Tamoxifen metabolism
Tryptophan metabolism
Oxidation by Cytochrome P450
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Vitamin D Receptor Pathway
Felbamate Metabolism
Lidocaine metabolism
Nifedipine Activity
Colchicine Metabolic Pathway
Irinotecan Pathway
Drug Induction of Bile Acid Pathway
Fatty Acid Omega Oxidation
Codeine and Morphine MetabolismWP702:Metapathway biotransformation
Aripiprazole Metabolic Pathway
Codeine and Morphine Metabolism
References
Ref 526196Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5.Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.
Ref 526196Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5.Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.