Drug Information

Drug General Information
Drug ID
D0B9MY
Former ID
DNC003545
Drug Name
8-Pyridin-4-yl-9H-purine-2,6-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534468]
Formula
C10H9N7
Canonical SMILES
C1=CN=CC=C1C2=NC3=C(N2)C(=NC(=N3)N)N
InChI
1S/C10H9N7/c11-7-6-9(17-10(12)15-7)16-8(14-6)5-1-3-13-4-2-5/h1-4H,(H5,11,12,14,15,16,17)
InChIKey
FRFATUHEQSVWHE-UHFFFAOYSA-N
PubChem Compound ID
457739
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [534468]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 534468J Med Chem. 1997 Sep 12;40(19):3032-9.Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
Ref 534468J Med Chem. 1997 Sep 12;40(19):3032-9.Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.