Drug Information

Drug General Information
Drug ID
D02HNM
Former ID
DNC001116
Drug Name
Phaclofen
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538671]
Formula
C9H13ClNO3P
InChI
InChI=1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
InChIKey
VSGNGLJPOGUDON-UHFFFAOYSA-N
CAS Number
CAS 108351-35-5
PubChem Compound ID
1641
PubChem Substance ID
5671788, 7978529, 8151214, 14823423, 17405525, 24278189, 26751635, 29220846, 47440471, 48035342, 48259452, 50067803, 50104322, 50104323, 52247142, 53778073, 57320962, 85088543, 85209238, 85231172, 90340885, 91721931, 92303274, 103064787, 103085802, 104298293, 117462745, 121361779, 123101031, 124750132, 124881011, 124881012, 126407148, 129519702, 134222867, 134340355, 135066309, 135090812, 135650815, 137009766, 162091866, 162311569, 162776879, 163564921, 164814867, 184548044, 204362019, 226675390, 241181562, 241337627
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Antagonist [536904], [537283]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 538671(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1091).
Ref 536904The role of group II and III metabotropic glutamate receptors in modulation of miniature synaptic activity in frog spinal cord motoneurons. Tsitologiia. 2008;50(9):747-56.
Ref 537283Astrocytes and Interneurons in Memory Processing in the Chick Hippocampus: Roles for G-Coupled Protein Receptors, GABA(B) and mGluR1. Neurochem Res. 2009 May 5.