Drug Information

Drug General Information
Drug ID
D03MUZ
Former ID
DNC008527
Drug Name
8-chloro-quinoline-3-carbonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529035]
Formula
C20H13Cl2FN6
Canonical SMILES
C1=CC(=C(C=C1NC2=C(C=NC3=C(C=C(C=C32)NCC4=CN=CN4)Cl)C#N<br />)Cl)F
InChI
1S/C20H13Cl2FN6/c21-16-4-12(1-2-18(16)23)29-19-11(6-24)7-27-20-15(19)3-13(5-17(20)22)26-9-14-8-25-10-28-14/h1-5,7-8,10,26H,9H2,(H,25,28)(H,27,29)
InChIKey
ONXROKMQGCSOMG-UHFFFAOYSA-N
PubChem Compound ID
17759555
Target and Pathway
Target(s) Stromelysin-1 Target Info Inhibitor [529035]
mRNA of human cot oncogene Target Info Inhibitor [529035]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04010:MAPK signaling pathway
Toll-like receptor signaling pathway
T cell receptor signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00054:Toll receptor signaling pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingtcr_pathway:TCR signaling in na&#xef
TCR signaling in na&#xef
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Ras signaling in the CD4+ TCR pathway
JNK signaling in the CD4+ TCR pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-389357:CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP75:Toll-like receptor signaling pathway
TCR Signaling Pathway
Insulin Signaling
MAPK Signaling Pathway
Structural Pathway of Interleukin 1 (IL-1)
TNF alpha Signaling Pathway
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Interleukin-1 signaling
Costimulation by the CD28 family
Regulation of toll-like receptor signaling pathway
References
Ref 529035J Biol Chem. 2007 Nov 16;282(46):33295-304. Epub 2007 Sep 11.Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
Ref 529035J Biol Chem. 2007 Nov 16;282(46):33295-304. Epub 2007 Sep 11.Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.