Drug Information

Drug General Information
Drug ID
D0BC2N
Former ID
DNC012975
Drug Name
Gly-Pip-Glu
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527903]
Formula
C13H21N3O6
Canonical SMILES
C1CCN(C(C1)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)CN
InChI
1S/C13H21N3O6/c14-7-10(17)16-6-2-1-3-9(16)12(20)15-8(13(21)22)4-5-11(18)19/h8-9H,1-7,14H2,(H,15,20)(H,18,19)(H,21,22)/t8-,9-/m0/s1
InChIKey
NEMPLRJUKFPLSV-IUCAKERBSA-N
PubChem Compound ID
25055596
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [527903]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [527903]
NMDA receptor subunit NR1 Target Info Inhibitor [527903]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Huntington's disease
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
Reelin signaling pathway
Reactome Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 527903Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6.New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.
Ref 527903Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6.New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.