TTD | Drug: D0ME9B

Drug General Information
Drug ID	D0ME9B
Former ID	DIB019382
Drug Name	compound 25
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531168]
Formula	C21H26N8OS
InChI	InChI=1S/C21H26N8OS/c1-12-9-29-18(16-6-23-24-7-16)8-22-21(29)20(25-12)26-19-5-17(27-31-19)15(4)28-10-13(2)30-14(3)11-28/h5-9,13-15H,10-11H2,1-4H3,(H,23,24)(H,25,26)/t13-,14+,15-/m1/s1
InChIKey	QBWKPGNFQQJGFY-QLFBSQMISA-N
PubChem Compound ID	46868971
PubChem Substance ID	99308102, 120903867, 123092407, 123108312, 180419003, 249565839
Target and Pathway
Target(s)	Aurora protein kinase	Target Info	Inhibitor	[531168]
	Serine/threonine-protein kinase Chk1	Target Info	Inhibitor	[531168]
	mRNA of Aurora B	Target Info	Inhibitor	[531168]
KEGG Pathway	Oocyte meiosishsa04110:Cell cycle
	p53 signaling pathway
	HTLV-I infection
	Viral carcinogenesis
Pathway Interaction Database	Fanconi anemia pathway
	p73 transcription factor network
	ATR signaling pathway
	Circadian rhythm pathway
	p53 pathwayaurora_b_pathway:Aurora B signaling
	Signaling by Aurora kinases
	Aurora C signaling
	FOXM1 transcription factor network
	Aurora A signaling
Reactome	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate ForminsR-HSA-176187:Activation of ATR in response to replication stress
	Processing of DNA double-strand break ends
	Presynaptic phase of homologous DNA pairing and strand exchange
	G2/M DNA damage checkpoint
	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	RHO GTPases Activate Formins
	Mitotic Prometaphase
WikiPathways	EGF/EGFR Signaling Pathway
	JAK/STAT
	Gastric Cancer Network 1
	Integrated Breast Cancer Pathway
	APC/C-mediated degradation of cell cycle proteinsWP707:DNA Damage Response
	Signaling by SCF-KIT
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Integrated Cancer pathway
	Cell Cycle
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP2757:Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Regulation of Microtubule Cytoskeleton
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	APC/C-mediated degradation of cell cycle proteins
References
Ref 531168	Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43.
Ref 531168	Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43.

Drug Information