Drug Information

Drug General Information
Drug ID
D0B9JP
Former ID
DNC011799
Drug Name
1-(3-Trifluoromethyl-phenyl)-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533476]
Structure
Formula
C11H13F3N2
Canonical SMILES
C1CN(CCN1)C2=CC=CC(=C2)C(F)(F)F
InChI
1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2
InChIKey
KKIMDKMETPPURN-UHFFFAOYSA-N
PubChem Compound ID
4296
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [533476]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [533476]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [533476]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Serotonergic synapsehsa04024:cAMP signaling pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 533476J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.
Ref 533476J Med Chem. 1986 May;29(5):630-4.Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.