Drug Information

Drug General Information
Drug ID
D0O7MW
Former ID
DNC011274
Drug Name
(5-methoxy-1H-indol-3-yl)methanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531223]
Formula
C10H12N2O
Canonical SMILES
COC1=CC2=C(C=C1)NC=C2CN
InChI
1S/C10H12N2O/c1-13-8-2-3-10-9(4-8)7(5-11)6-12-10/h2-4,6,12H,5,11H2,1H3
InChIKey
CAHOMULUOHSWPI-UHFFFAOYSA-N
PubChem Compound ID
14702424
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Inhibitor [531223]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 531223J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
Ref 531223J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.