Drug Information

Drug General Information
Drug ID
D09LEK
Former ID
DNC005645
Drug Name
4-(5-Phenyl-oxazol-2-ylamino)-benzenesulfonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527458]
Formula
C15H13N3O3S
Canonical SMILES
C1=CC=C(C=C1)C2=CN=C(O2)NC3=CC=C(C=C3)S(=O)(=O)N
InChI
1S/C15H13N3O3S/c16-22(19,20)13-8-6-12(7-9-13)18-15-17-10-14(21-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)(H2,16,19,20)
InChIKey
OKFOIEMZTIOWQH-UHFFFAOYSA-N
PubChem Compound ID
5329850
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 3 Target Info Inhibitor [527458]
mRNA of VEGFR1 Target Info Inhibitor [527458]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [527458]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesionhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Endocytosis
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
VEGF signaling pathway
Proteoglycans in cancer
NetPath Pathway TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endotheliumglypican_1pathway:Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY network
Reactome VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WikiPathways Signaling by VEGFWP306:Focal Adhesion
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Angiogenesis
References
Ref 527458J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
Ref 527458J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.