Drug Information

Drug General Information
Drug ID
D0WF7L
Former ID
DCL000499
Drug Name
Brilinta
Synonyms
Brilique; Ticagrelor; AR-C126532; AZD-6140; Ticagrelor (USAN/INN)
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Approved [531783], [539115]
Company
AstraZeneca
Formula
C23H28F2N6O4S
InChI
InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
InChIKey
OEKWJQXRCDYSHL-FNOIDJSQSA-N
CAS Number
CAS 274693-27-5
PubChem Compound ID
9871419
PubChem Substance ID
14836432, 14860737, 24162024, 45293678, 49684205, 57373617, 77877844, 92729712, 96025700, 103554312, 123051091, 124759706, 126644885, 126666051, 135649975, 136345665, 137171656, 139857160, 152040158, 152258075, 160645837, 160646914, 162011636, 163346229, 163383616, 164178089, 164765598, 165245536, 170501033, 171063069, 172914585, 174528632, 175267325, 175427101, 185974765, 189657701, 198993342, 211534943, 223384813, 223666650, 224638556, 228139491, 247988848, 249582784, 249807649, 249807650, 249816423, 251966736, 251970939, 252216468
SuperDrug ATC ID
B01AC24
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Antagonist [550288]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 539115(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1765).
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).